@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/us/codex-mopa/PlanDefinition/RegimenPHD> a fhir:PlanDefinition ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:Resource.id [ fhir:value "RegimenPHD"] ;
  fhir:Resource.meta [
     fhir:Meta.profile [
       fhir:value "http://hl7.org/fhir/us/codex-mopa/StructureDefinition/anticancer-regimen-plandefinition" ;
       fhir:index -1 ;
       fhir:link <http://hl7.org/fhir/us/codex-mopa/StructureDefinition/anticancer-regimen-plandefinition>
     ]
  ] ;
  fhir:Resource.language [ fhir:value "en"] ;
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "extensions" ] ;
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n  <table class=\"narrative-table\">\n    <tbody>\n<tr>\n\n\n<th colspan=\"2\" scope=\"row\" class=\"row-header\">Metadata</th>\n\n\n</tr>\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Title</th>\n\n\n\n<td class=\"content-container\">PHD: Pertuzumab + Trastuzumab + Docetaxel — Metastatic HER2+ Breast Cancer</td>\n\n\n</tr>\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Version</th>\n\n\n\n<td class=\"content-container\">0.1.1-snapshot-080926</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Experimental</th>\n\n\n\n<td class=\"content-container\">true</td>\n\n\n</tr>\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Subject Type</th>\n\n\n\n<td class=\"content-container\">\n    Malignant neoplasm of breast\n\n\n</td>\n\n\n</tr>\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Jurisdiction</th>\n\n\n\n<td class=\"content-container\">\n    United States of America\n\n\n</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Steward (Publisher)</th>\n\n\n\n<td class=\"content-container\">HL7 International / Clinical Interoperability Council</td>\n\n\n</tr>\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Steward Contact</th>\n\n\n\n<td class=\"content-container\">HL7 International / Clinical Interoperability Council</td>\n\n\n</tr>\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Description</th>\n\n\n\n<td class=\"content-container\"><div><p>PHD regimen every 21 days for HER2+ metastatic breast cancer. Standard of care per CLEOPATRA trial.</p>\n</div></td>\n\n\n</tr>\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Type</th>\n\n\n\n<td class=\"content-container\">\n    Order Set\n\n\n</td>\n\n\n</tr>\n\n\n\n\n<tr>\n\n\n<th colspan=\"2\" scope=\"row\" class=\"row-header\">PlanDefinition Action</th>\n\n\n</tr>\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Id</th>\n\n\n\n<td class=\"content-container\">pertuzumab-phd</td>\n\n\n</tr>\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Title</th>\n\n\n\n<td class=\"content-container\">Pertuzumab 840 mg IV (cycle 1), then 420 mg IV q21d</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Timing</th>\n\n\n\n<td class=\"content-container\">Once per 21 days</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th colspan=\"2\" scope=\"row\" class=\"row-header\">PlanDefinition Action</th>\n\n\n</tr>\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Id</th>\n\n\n\n<td class=\"content-container\">trastuzumab-phd</td>\n\n\n</tr>\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Title</th>\n\n\n\n<td class=\"content-container\">Trastuzumab 8 mg/kg IV (cycle 1), then 6 mg/kg IV q21d</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Timing</th>\n\n\n\n<td class=\"content-container\">Once per 21 days</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th colspan=\"2\" scope=\"row\" class=\"row-header\">PlanDefinition Action</th>\n\n\n</tr>\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Id</th>\n\n\n\n<td class=\"content-container\">docetaxel-phd</td>\n\n\n</tr>\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Title</th>\n\n\n\n<td class=\"content-container\">Docetaxel 75 mg/m² IV — Day 1 of each 21-day cycle</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Timing</th>\n\n\n\n<td class=\"content-container\">Once per 21 days</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n  <th colspan=\"2\" scope=\"row\" class=\"row-header\">Generated using version 0.5.4 of the sample-content-ig Liquid templates</th>\n</tr>\n\n    </tbody>\n  </table>\n</div>"
  ] ;
  fhir:PlanDefinition.url [ fhir:value "http://hl7.org/fhir/us/codex-mopa/PlanDefinition/RegimenPHD"] ;
  fhir:PlanDefinition.version [ fhir:value "0.1.1-snapshot-080926"] ;
  fhir:PlanDefinition.name [ fhir:value "RegimenPHD"] ;
  fhir:PlanDefinition.title [ fhir:value "PHD: Pertuzumab + Trastuzumab + Docetaxel — Metastatic HER2+ Breast Cancer"] ;
  fhir:PlanDefinition.type [
     fhir:CodeableConcept.coding [
       fhir:index -1 ;
       fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/plan-definition-type" ] ;
       fhir:Coding.code [ fhir:value "order-set" ] ;
       fhir:Coding.display [ fhir:value "Order Set" ]
     ]
  ] ;
  fhir:PlanDefinition.status [ fhir:value "active"] ;
  fhir:PlanDefinition.experimental [ fhir:value "true"^^xsd:boolean] ;
  fhir:PlanDefinition.subjectCodeableConcept [
     fhir:CodeableConcept.coding [
       fhir:index -1 ;
       a sct:254837009 ;
       fhir:Coding.system [ fhir:value "http://snomed.info/sct" ] ;
       fhir:Coding.code [ fhir:value "254837009" ] ;
       fhir:Coding.display [ fhir:value "Malignant neoplasm of breast" ]
     ]
  ] ;
  fhir:PlanDefinition.date [ fhir:value "2026-09-08T18:17:28-04:00"^^xsd:dateTime] ;
  fhir:PlanDefinition.publisher [ fhir:value "HL7 International / Clinical Interoperability Council"] ;
  fhir:PlanDefinition.contact [
     fhir:index -1 ;
     fhir:ContactDetail.name [ fhir:value "HL7 International / Clinical Interoperability Council" ] ;
     fhir:ContactDetail.telecom [
       fhir:index -1 ;
       fhir:ContactPoint.system [ fhir:value "url" ] ;
       fhir:ContactPoint.value [ fhir:value "http://www.hl7.org/Special/committees/cic" ]
     ], [
       fhir:index -1 ;
       fhir:ContactPoint.system [ fhir:value "email" ] ;
       fhir:ContactPoint.value [ fhir:value "ciclist@lists.HL7.org" ]
     ]
  ] ;
  fhir:PlanDefinition.description [ fhir:value "PHD regimen every 21 days for HER2+ metastatic breast cancer. Standard of care per CLEOPATRA trial."] ;
  fhir:PlanDefinition.jurisdiction [
     fhir:index -1 ;
     fhir:CodeableConcept.coding [
       fhir:index -1 ;
       fhir:Coding.system [ fhir:value "urn:iso:std:iso:3166" ] ;
       fhir:Coding.code [ fhir:value "US" ] ;
       fhir:Coding.display [ fhir:value "United States of America" ]
     ]
  ] ;
  fhir:PlanDefinition.action [
     fhir:index -1 ;
     fhir:Element.id [ fhir:value "pertuzumab-phd" ] ;
     fhir:PlanDefinition.action.title [ fhir:value "Pertuzumab 840 mg IV (cycle 1), then 420 mg IV q21d" ] ;
     fhir:PlanDefinition.action.timingTiming [
       fhir:Timing.repeat [
         fhir:Timing.repeat.period [ fhir:value "21"^^xsd:decimal ] ;
         fhir:Timing.repeat.periodUnit [ fhir:value "d" ]
       ]
     ]
  ], [
     fhir:index -1 ;
     fhir:Element.id [ fhir:value "trastuzumab-phd" ] ;
     fhir:PlanDefinition.action.title [ fhir:value "Trastuzumab 8 mg/kg IV (cycle 1), then 6 mg/kg IV q21d" ] ;
     fhir:PlanDefinition.action.timingTiming [
       fhir:Timing.repeat [
         fhir:Timing.repeat.period [ fhir:value "21"^^xsd:decimal ] ;
         fhir:Timing.repeat.periodUnit [ fhir:value "d" ]
       ]
     ]
  ], [
     fhir:index -1 ;
     fhir:Element.id [ fhir:value "docetaxel-phd" ] ;
     fhir:PlanDefinition.action.title [ fhir:value "Docetaxel 75 mg/m² IV — Day 1 of each 21-day cycle" ] ;
     fhir:PlanDefinition.action.timingTiming [
       fhir:Timing.repeat [
         fhir:Timing.repeat.period [ fhir:value "21"^^xsd:decimal ] ;
         fhir:Timing.repeat.periodUnit [ fhir:value "d" ]
       ]
     ]
  ] .

# - ontology header ------------------------------------------------------------

<http://hl7.org/fhir/us/codex-mopa/PlanDefinition/RegimenPHD.ttl> a owl:Ontology ;
  owl:imports fhir:fhir.ttl ;
  owl:versionIRI <http://build.fhir.org/us/codex-mopa/PlanDefinition/RegimenPHD.ttl> .

# -------------------------------------------------------------------------------------