{
  "resourceType" : "PlanDefinition",
  "id" : "RegimenTH",
  "meta" : {
    "profile" : ["http://hl7.org/fhir/us/codex-mopa/StructureDefinition/anticancer-regimen-plandefinition"]
  },
  "language" : "en",
  "text" : {
    "status" : "extensions",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n  <table class=\"narrative-table\">\n    <tbody>\n<tr>\n\n\n<th colspan=\"2\" scope=\"row\" class=\"row-header\">Metadata</th>\n\n\n</tr>\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Title</th>\n\n\n\n<td class=\"content-container\">TH: Paclitaxel + Trastuzumab (Weekly) — HER2+ Breast Cancer</td>\n\n\n</tr>\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Version</th>\n\n\n\n<td class=\"content-container\">0.1.1-snapshot-080926</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Experimental</th>\n\n\n\n<td class=\"content-container\">true</td>\n\n\n</tr>\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Subject Type</th>\n\n\n\n<td class=\"content-container\">\n    Malignant neoplasm of breast\n\n\n</td>\n\n\n</tr>\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Jurisdiction</th>\n\n\n\n<td class=\"content-container\">\n    United States of America\n\n\n</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Steward (Publisher)</th>\n\n\n\n<td class=\"content-container\">HL7 International / Clinical Interoperability Council</td>\n\n\n</tr>\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Steward Contact</th>\n\n\n\n<td class=\"content-container\">HL7 International / Clinical Interoperability Council</td>\n\n\n</tr>\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Description</th>\n\n\n\n<td class=\"content-container\"><div><p>Weekly Paclitaxel + Trastuzumab for 12 weeks for HER2+ early breast cancer.</p>\n</div></td>\n\n\n</tr>\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Type</th>\n\n\n\n<td class=\"content-container\">\n    Order Set\n\n\n</td>\n\n\n</tr>\n\n\n\n\n<tr>\n\n\n<th colspan=\"2\" scope=\"row\" class=\"row-header\">PlanDefinition Action</th>\n\n\n</tr>\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Id</th>\n\n\n\n<td class=\"content-container\">paclitaxel-th</td>\n\n\n</tr>\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Title</th>\n\n\n\n<td class=\"content-container\">Paclitaxel 80 mg/m² IV — Day 1 of each 7-day cycle</td>\n\n\n</tr>\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Description</th>\n\n\n\n<td class=\"content-container\">Paclitaxel 80 mg/m² IV over 1 hour, weekly (day 1 of 7-day cycle) x12 doses</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Timing</th>\n\n\n\n<td class=\"content-container\">Count 12  times, Once per 7 days</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th colspan=\"2\" scope=\"row\" class=\"row-header\">PlanDefinition Action</th>\n\n\n</tr>\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Id</th>\n\n\n\n<td class=\"content-container\">trastuzumab-th</td>\n\n\n</tr>\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Title</th>\n\n\n\n<td class=\"content-container\">Trastuzumab 4 mg/kg (loading) then 2 mg/kg IV weekly</td>\n\n\n</tr>\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Description</th>\n\n\n\n<td class=\"content-container\">Trastuzumab 4 mg/kg IV loading dose week 1, then 2 mg/kg IV weekly (day 1 of 7-day cycle) x11 doses</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n\n\n<th scope=\"row\" class=\"row-header\">Timing</th>\n\n\n\n<td class=\"content-container\">Count 12  times, Once per 7 days</td>\n\n\n</tr>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<tr>\n  <th colspan=\"2\" scope=\"row\" class=\"row-header\">Generated using version 0.5.4 of the sample-content-ig Liquid templates</th>\n</tr>\n\n    </tbody>\n  </table>\n</div>"
  },
  "url" : "http://hl7.org/fhir/us/codex-mopa/PlanDefinition/RegimenTH",
  "version" : "0.1.1-snapshot-080926",
  "name" : "RegimenTH",
  "title" : "TH: Paclitaxel + Trastuzumab (Weekly) — HER2+ Breast Cancer",
  "type" : {
    "coding" : [{
      "system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
      "code" : "order-set",
      "display" : "Order Set"
    }]
  },
  "status" : "active",
  "experimental" : true,
  "subjectCodeableConcept" : {
    "coding" : [{
      "system" : "http://snomed.info/sct",
      "code" : "254837009",
      "display" : "Malignant neoplasm of breast"
    }]
  },
  "date" : "2026-09-08T18:17:28-04:00",
  "publisher" : "HL7 International / Clinical Interoperability Council",
  "contact" : [{
    "name" : "HL7 International / Clinical Interoperability Council",
    "telecom" : [{
      "system" : "url",
      "value" : "http://www.hl7.org/Special/committees/cic"
    },
    {
      "system" : "email",
      "value" : "ciclist@lists.HL7.org"
    }]
  }],
  "description" : "Weekly Paclitaxel + Trastuzumab for 12 weeks for HER2+ early breast cancer.",
  "jurisdiction" : [{
    "coding" : [{
      "system" : "urn:iso:std:iso:3166",
      "code" : "US",
      "display" : "United States of America"
    }]
  }],
  "action" : [{
    "id" : "paclitaxel-th",
    "title" : "Paclitaxel 80 mg/m² IV — Day 1 of each 7-day cycle",
    "description" : "Paclitaxel 80 mg/m² IV over 1 hour, weekly (day 1 of 7-day cycle) x12 doses",
    "timingTiming" : {
      "repeat" : {
        "count" : 12,
        "period" : 7,
        "periodUnit" : "d"
      }
    }
  },
  {
    "id" : "trastuzumab-th",
    "title" : "Trastuzumab 4 mg/kg (loading) then 2 mg/kg IV weekly",
    "description" : "Trastuzumab 4 mg/kg IV loading dose week 1, then 2 mg/kg IV weekly (day 1 of 7-day cycle) x11 doses",
    "timingTiming" : {
      "repeat" : {
        "count" : 12,
        "period" : 7,
        "periodUnit" : "d"
      }
    }
  }]
}